Anne Chiaramello, PhD
George Washington University School of Medicine
Dr. Anne Chiaramello, Ph.D., Professor of Anatomy and Cell Biology at the George Washington University School of Medicine and Health Sciences is the founding Director of the Mito-EpiGen Program. It provides an interactive infrastructure for collaborative investigations between translational researchers and clinicians, and serves as a hub for patient advocacy groups.She discovered a novel pharmaco-epigenomic approach to induce mitochondrial biogenesis and metabolic reprogramming. She applied this concept to develop a pharmaco-epigenomic therapeutic avenue for rescuing the mitochondrial phenotype in patient-derived fibroblasts. Her translational and clinical research on LHON-Plus and MELAS is funded by the National Center for Advancing Translational Sciences. As the sponsor of a Research IND application, she recently received authorization by the U.S. Food and Drug Administration to conduct the first basket trial to test her small molecule drug-based therapeutic approach in patients with LHON-Plus or MELAS enrolled in a phase 1/2a clinical trial.